Affiliation:
1. Federal Research Center Computer Science and Control, Russian Academy of Sciences
2. Ivanovo State Medical Academy
Abstract
Hepatoprotectors are necessary for the treatment of alcoholic and non-alcoholic (including medicinal) liver damage. This paper presents the results of a study of the Laennec hepatoprotector, produced on the basis of pharmaceutically standardized human placental hydrolysates (HPH). The use of HSP in toxic liver damage with alcohol or paracetamol led to a significant decrease in markers of liver dysfunction (AST, ALT, bilirubin, MDA), which increase when the models are reproduced. The hepatoprotective effect of Laennec was confi rmed by the results of histological studies, indicating a reduction in infl ammation and preservation of the liver parenchyma. Histological studies also indicated the nephroprotective and cardioprotective effects of Laennec in liver damage with both alcohol and paracetamol.
Publisher
LLC Global Media Technology
Subject
Gastroenterology,Hepatology
Reference14 articles.
1. Reference book of medicines Vidal. Moscow. AstraPharmService, 2021, 1298 P. (in Russ.)
2. Gromova O.A., Torshin I. Yu., Zgoda V. G., Tomilova I. K. Molecular mechanisms of action of the drug Laennec against the formation of metabolic syndrome and obesity. Th erapy. 2017. No. 5. pp. 73–83. (in Russ.)
3. Tohda C., Kogure C., Nomoto K., de Toledo A., Yang X., Hirano E. A Novel Heptapeptide, GPPGPAG Transfers to the Brain, and Ameliorates Memory Dysfunction and Dendritic Atrophy in Alzheimer’s Disease Model Mice. Front Pharmacol. 2021;12:680652. Published 2021 May 14. doi:10.3389/fphar.2021.680652
4. Maksimov V. A., Torshin I. Yu., Chuchalin A. G., Lazebnik L. B., Tkacheva O. N., Strazhesko I. D., Gromova O. A. Efficacy and safety of the polypeptide drug (Laennec) in therapy for COVID-19. Experimental and clinical gastroenterology. 2020;178(6): 55–63. (in Russ.) doi: 10.31146/1682–8658-ecg-178–6–55–63
5. Sayfutdinov R. R., Maksimov V. A., Khasanov R., Akhmedov R. U., Salyakhova E. V., Sayfutdinov R. G. Possibilities of Using Placenta Hydrolysate in Patients with COVID-19. EC Gastroenterology and Digestive System. 2021;8(11): 91–101. (in Russ.)
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