Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats-Reference-Cited by-同舟云学术

Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats

Published:2024-01-22 Issue:4 Volume: Page:23-31
ISSN:2686-8830
Container-title:Pharmacokinetics and Pharmacodynamics
language:
Short-container-title:Fk&Fd

Author:

Bogacheva T. E.¹^ORCID,Kalacheva A. G.¹^ORCID,Gromova O. A.²^ORCID,Torshin I. Yu.²^ORCID,Grishina T. R.¹,Demidov V. I.¹^ORCID

Affiliation:

1. FSBEI HE "Ivanovo State Medical Academy" MOH Russia

2. FRC "Computer Science and Control" RAS

Abstract

Palm oil is a component of most food products, characterized by a high content of palmitic and oleic acids, an excess of which leads to the formation of tripalmitins, practically do not respond to enzymatic hydrolysis by lipoprotein lipase and predetermine the development of obesity, type 2 diabetes mellitus and atherosclerosis. This paper presents the results of a study of the drug Laennek, produced on the basis of standardized hydrolysates of the human placenta (HRP). The use of HRP under the influence of excessive consumption of palm oil in the diet led to a significant decrease in markers of liver dysfunction (ALT), which increase with an enriched diet of refined palm oil (bilirubin, total protein, ALT, AST). The hepatoprotective effect of Laennek was confirmed by the results of histological and biochemical studies indicating a decrease in the severity and prevalence of fatty liver dystrophy.

Publisher

Publishing House OKI

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