A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid

Author:

Lim Sung HaORCID,Kim Eun Jung,Lee Chung Hyuk,Park Gi Hyun,Yoo Kang Min,Nam Sung Ju,Shin Kyong-Oh,Park Kyungho,Choi Eung HoORCID

Publisher

S. Karger AG

Subject

Dermatology,Pharmacology,Physiology,General Medicine

Reference86 articles.

1. Elias PM. Epidermal lipids, barrier function, and desquamation. J Invest Dermatol. 1983 Jun;80(1 Suppl):44s–9s.

2. Gray GM, White RJ, Williams RH, Yardley HJ. Lipid composition of the superficial stratum corneum cells of pig epidermis. Br J Dermatol. 1982 Jan;106(1):59–63.

3. Sheu HM, Lee JY, Kuo KW, Tsai JC. Permeability barrier abnormality of hairless mouse epidermis after topical corticosteroid: characterization of stratum corneum lipids by ruthenium tetroxide staining and high-performance thin-layer chromatography. J Dermatol. 1998 May;25(5):281–9.

4. Sheu HM, Lee JY, Chai CY, Kuo KW. Depletion of stratum corneum intercellular lipid lamellae and barrier function abnormalities after long-term topical corticosteroids. Br J Dermatol. 1997 Jun;136(6):884–90.

5. Kao JS, Fluhr JW, Man MQ, Fowler AJ, Hachem JP, Crumrine D, et al. Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities. J Invest Dermatol. 2003 Mar;120(3):456–64.

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