Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

Author:

Bae Jong Bin,Kim You Joung,Han Ji Won,Kim Tae Hui,Park Joon Hyuk,Lee Seok Bum,Lee Jung Jae,Jeong Hyun Ghang,Kim Jeong Lan,Jhoo Jin Hyeong,Yoon Jong Chul,Kim Ki Woong

Abstract

Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD. © 2014 S. Karger AG, Basel

Publisher

S. Karger AG

Subject

Psychiatry and Mental health,Cognitive Neuroscience,Geriatrics and Gerontology

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