Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates-Reference-Cited by-同舟云学术

Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

Published:2020 Issue:5 Volume:117 Page:545-554
ISSN:1661-7800
Container-title:Neonatology
language:en
Short-container-title:Neonatology

Author:

Omer Murwan,Melo Ashanty Maggvie,Kelly Lynne,Mac Dermott Emma Jane,Leahy Timothy Ronan,Killeen Orla,Saugstad Ola Didrik^ORCID,Savani Rashmin C.,Molloy Eleanor J.

Abstract

Infection and persistent inflammation have a prominent role in the pathogenesis of brain injury and cerebral palsy, as well as other conditions associated with prematurity such as bronchopulmonary dysplasia. The NLRP3 inflammasome-interleukin (IL)-1β pathway has been extensively studied in adults and pre-clinical models, improving our understanding of innate immunity and offering an attractive therapeutic target that is already contributing to clinical management in many auto-inflammatory disorders. IL-1 blockade has transformed the course and outcome of conditions such as chronic infantile neurological, cutaneous, articular (CINCA/NOMID) syndrome. Inflammasome activation and upregulation has recently been implicated in neonatal brain and lung inflammatory disease and may be a novel therapeutic target.

Publisher

S. Karger AG

Subject

Developmental Biology,Pediatrics, Perinatology and Child Health

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