Enhancement in aqueous solubility of sulindac medicine by using the micellar solution of ionic and non-ionic surfactants

Abstract

In the science of pharmacology, solubility plays a crucial role in the efficacy and bioavailability of the drug. Utilizing solubility features to improve the bioavailability and pharmacological effect of diverse weakly soluble substances, is an arduous task for pharmaceutical experts and researchers. Particle size, surface area, physicochemical qualities, physical forms of drugs, solvents and surfactant usage are parameters that influence solubility. The objective of the current study was to enhance the solubility of the non-steroidal anti-inflammatory drug (NSAID): Sulindac. The micellar solutions method was employed with different surfactants to increase the efficiency. Both nonionic (Tween 20, 40, 60 and 80 with Brij 30, 35 and 56) and ionic (SDS, SDBS, CTAB, TTAB and DTAB) surfactants were investigated for their effect on drug solubility in aqueous solution. Various parameters of surfactant solutions such as aggregation number, micelle-water partition coefficient (KM), molar solubilization ratio (MSR), Gibbs energy of solubilization (∆Gº s), size of micelle and binding constant of the drug micelles were measured. Finding reveals that the use of mentioned surfactant is an excellent approach to enhancing the solubility of sulindac. Furthermore, the present work provides an understanding of the relation of aqueous solubility with aggregation number and structure of surfactants used.