Subchronic intraperitoneal toxicity of Sio2NPs on body weight and thyroid gland hormones in female Rats

Abstract

This study investigated the toxicity effect of Sio2NPs on body weight and thyroid gland in female rats; the experiment was included. The experimental animals were randomly divided into three groups, including two treatment groups ( treated with a low dose (25mg/Kg ) and high dose (100mg/Kg of body weight) of sio2 NPs and one group as a control. Each group of them was divided into three subgroups according to the injection periods of exposure (10, 20, and 30) days daily, then measure the body weight and Thyroid function hormones (T3, T4, TSH), the results showed that there was a significant decrease (p<0.05) in the body weight of animals that exposed to SiO2 NPs at two doses (25 and 100 mg/kg) during (10 days) while increased during (20, 30 days) but the highest value recorded in the animals that were treated for (30 days) at both doses. On the other side, the T3 findings recorded a significant decrease (p< 0.05) for the animals that exposed to SiO2 NPs at low and high doses (25 and 100 mg/kg) (during (10 days) when compared with the control group As well as, there was a significant decrease (p< 0.05) in the level of T3 for all animals that treated with these doses during (20 and 3 days) in serum of animals that were treated with both doses of SiO2 NPs when compared with the control group (p< 0.05), while T4 showed s decreasing in the treated group during (10 and 20, 30 days) compared to a control group with highly significant ((p< 0.05), finally while TSH showed a highly increasing in treated group during (10 and 20, 30 days) compared to control group (p< 0.05). The study revealed that Exposure to Sio2NPs at different concentrations caused structural and functional and in the thyroid gland, characterized decrease in T3 and T4 hormone levels and an increase in the TSH hormone level and caused hypothyroidism This led to a decrease in the metabolism process and thus the body weight of animals gained a significant increase. Keywords: nanoparticles, Sio2NPs, Thyroid gland, T3, T4, TSH, Body weight, female rats.