Synthesis, characterization, and biological activity of new metal complexes
derived from 1,2,4-triazole Schiff base ligand
Author:
Al Hassani Rehab A.M.1, Balakit Asim A.2, Khuder Hassan3
Affiliation:
1. Department of Chemistry, College of Science, Mustansiriyah University, Baghdad-Iraq 2. 2College of Pharmacy, University of Babylon, Hilla-Iraq 3. Science Department, College of Basic Education, University of Babylon, Hilla-Iraq
Abstract
The present study involves the synthesis of a new Schiff base ligand (L) and its
complexes(C1-C5) with Co (II), Ni (II), Cu (II), Pd (II), and Pt (IV). The ligand
was synthesized by the condensation reaction of 4-Amino-5-(3,4,5-trimethoxy
phenyl)-4H-1,2,4-triazole-3-thione (1) with 2-hydroxy-1-naphthaldehyde (2). The
structures of the new ligand and its complexes were confirmed by FT-IR, UVvisible, 1H NMR, 13C NMR, mass spectrometry, microelement analysis
(CHNS), atomic absorption flame (AAF) spectrophotometry, conductivity, and
magnetic susceptibility analysis. The antibacterial activity of the ligands (L) and
their complexes (C1–C5) was examined in vitro against the gram-positive and
gram-negative bacteria Staphylococcus aureus and Escherichia coli, with the
(MIC) values being compared to two common antibiotics. Furthermore,
Aspergillus flavus and Penicillium spp. were used as test subjects for the novel
compounds' antifungal properties.
Keywords: Schiff base, triazole, metal complexes, antibacterial, antifungal.
Publisher
Clinical Biotec
Subject
Infectious Diseases,Applied Microbiology and Biotechnology,Epidemiology,Biotechnology
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