Protective Role of Ethanolic Alcoholic Extract of Boswellia carterii Against Some Physiological and Histological Disorders Induced by Amoebic Infection Experimentally

Abstract

The current study was designed to prospect the protective effect of alcoholic extract of Boswellia carterii in some physiological parameters and histopathological changes caused by amoebic infection experimentally of female rats; thirtytwo adult female rats were used. It was divided into four groups: the first group received physiological saline as the control group, the second group was infected experimentally with amoeba (Entamoeba histolytica), which was administrated (1 mL/Amoebic suspension /Animal /day) for 10 days, and the third and fourth groups treated with alcoholic extract of plant at (1 mL /animal/day) for one and two months respectively after amoebic infection was ten days. The results indicated a significant decrease (P≤0.05) in body weight and liver enzymes (ALT, AST, ALP) of the amoebic group compared with the control group. In contrast, a significant increase (P≤0.05) in these parameters occurred by using alcohol extract of the plant compared with the infected group by amoeba. Also, the phagocytosis factor and kidney functions (urea and creatinine) were increased significantly (P≤0.05) when amoebic infection compared with the control group. That alcoholic extract caused a significant decline (P≤0.05) for natural levels in these parameters compared with the amoebic group. On the other hand, the present results reported that administering an alcoholic extract of Boswellia carterii caused improvement in the histopathological damage of the kidney and liver, which resulted from amoebic infection experimentally by Entamoeba histolytica. These histological changes in the kidney comprised fibrosis, inflammation, structural changes in glomeruli as absence, shrinkage and death of glomeruli, enlargement of Bowman's space, congestion and hemorrhage. While in livers, that included infiltration of inflammatory cells, enlargement of the sinusoid, congestion, and severe hemorrhage. Keywords: Boswellia carterii, Liver Enzymes, Kidney