Affiliation:
1. Department of Veterinary Surgery and Obstetric, University of Basrah, Basrah, Iraq
Abstract
Tendon is a mechanical bridge that transforms the force generated by muscle contraction into movement. This tissue is well known for its low cellularity and vascularity; therefore, any tendon damage is characterized by a slow and inefficient
healing process resulting in mechanically, structurally, and functionally inferior
tissue. The current study aimed to evaluate the effect of the regenerative capacity of
xenogeneic platelet-rich fibrin on the acceleration of Achilles tendon healing in
rabbits. 24 adult rabbits weighing (1.5-2) kg were used in this study. The animals
were divided equally into three groups: A-PRF group, in which the tendon defect
was treated with xenogeneic Advance-platelet rich fibrin; L-PRF group, which used
xenogeneic for tendon defect treatment; and control groups treated with normal
saline. Clinical investigation of the rabbits during the experiment period revealed
improvement of lameness and disappearance of swelling and redness at the operation site in the A-PRF and L-PRF groups compared to the control group at the same
period. Histopathological examination revealed a good tendon healing process in
the A-PRF group characterized by a highly organized Achilles tendon and lightly
stained collagen fibers arranged in parallel. At the same time, these are less evident
in the L-PRF group. In conclusion, this study suggests that xenogeneic Advanced
platelet-rich fibrin treatment can be useful as a biomaterial for accelerating Achilles
tendon healing in rabbits and this biomaterial.
Keywords: Xenogeneic platelet-rich fibrin; Rabbit Achilles tendon; tendon healing; Advanced platelet-rich fibrin; Iraq.
Subject
Infectious Diseases,Applied Microbiology and Biotechnology,Epidemiology,Biotechnology
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