Antibacterial and anti-biofilm properties of biosynthesized Silver nanoparticles using Sumac (Rhus coriaria L.) extracts against some pathogenic bacteria

Abstract

Multidrug-resistant bacteria have contributed to a rise in morbidity and death from microbial infections, making it more difficult to treat illnesses caused by resistant pathogenic bacteria. There is a growing interest in using nanoparticles as biomaterials around the globe. Nanoparticles might become a crucial, feasible therapeutic alternative for treating infections resistant to several drugs. Currently, they are recognized as feasible alternatives or additions to conventional antimicrobials. Nanotechnology focuses on developing eco-friendly methods for producing nanoparticles. The current work aims to generate a quick, ecologically friendly approach for synthesizing silver nanoparticles utilizing aqueous and alcohol sumac plant extracts. These silver nanoparticles appear synthesized and capped by sumac extract bioactive components. FTIR, XRD, SEM, AAS, EDX, AFM, and UV-Vis spectroscopy were used to determine the nanoparticle structure, shape, and optical properties. Within 15 minutes, the AgNPs had formed. The aqueous and alcoholic sumac extracts resulted in silver nanoparticles with an average particle size of 43.82 nm and 39.55 nm, respectively. Against the multi-drug-resistant clinical isolates, silver nanoparticles from both extracts had good antibacterial activity (Staphylococcus aureus, Acinetobacter baumannii, Enterococcus faecalis, and Pseudomonas aeruginosa). Also, these nanoparticles had an inhibitory effect on the productivity of the biofilm virulence factor. For this study with highly significant differences (P≤0.01). Keywords: Silver nanoparticles, Green synthesis, Rhus coriaria L., Sumac, antibacterial activity, antibiofilm activity; multidrug-resistant bacteria.