The Correlation between some Risk Factors and the Patients with Inherited Hemophilia Gender in the Province of Kerbala.

Abstract

The transcendent side effects normally correlate with the patients' organic sex, which signifies that the crippling instruments of bleeding problems are gendered, bleeding turmoil hereditary diseases. This includes debilitated blood clotting, which might prompt a handicap. The patients' gender determines the mechanism of inactivation of bleeding disorders because of the prevailing symptoms difference. It usually depends on the biological sex. In this study, ninety-one (91) of the male and female hemophilic patients had complete information taken for this study from their medical records in the special department for treating patients in the hospital of the city of Kerbala. The study aims to determine the association between a hemophilic patient's gender and the various risk factors and reveal how much these factors impact sex. The results of the current paper confirmed that males 86% were more affected than females 14% by hereditary hemorrhagic disease due to the correlation between this disease and the chromosome of sex. The age of the disease diagnosis in male patients was between one and five years. In female patients, a specific age of diagnosis did not appear. There were differences between sexes at the age of ten (10) of diagnosis and younger than that. The affected males were suffering from VIII and IX factors deficiency 54.94% and 23.07%, respectively, while the females did not suffer from the previously mentioned deficiency of those factors but suffered from XI factor deficiency 14.28%. Parental consanguinity significantly impacted 32.96% of the number of injuries in males, including the first 15.3 % and the fourth degree of kinship 17.5%. Concerning results of the history, they manifested that males are more than females in Epistaxis, Skin Bleeding, Join Bleeding, Muscle Bleeding, Bleeding after Trauma. No differences were found in rates of WBC and the amount of clotting factor deficiency, while we found a significant difference in platelet mean between the two genders. Conclusion: According to the data, hemophilia A and B are more frequent than C of all the studied hereditary bleeding diseases. The most prevalent symptom among male patients is skin bleeding. Consanguineous marriage is the main cause of the disease. Although the disease is linked to the sex chromosome, females are also affected. Keywords: hemophilia, gender, risk factors, family history of bleeding, VIII factor deficiency, IX factor deficiency.