Affiliation:
1. 1College of Medicine, University of Baghdad, Iraq.
2. Baghdad Teaching Hospital, Iraq
Abstract
All major organs may be impacted by the connective disease systemic
lupus erythematosus, a separate risk factor for coronary artery disease (CAD). Adhesion molecules like intercellular adhesion molecules (ICAM) and vascular cell
adhesion molecules (VCAM) can detect endothelial damage and dysfunction,
which appear to play a crucial role. This study investigated whether people with
SLE had elevated subclinical and clinical atherosclerosis risk factors. Traditional
CAD risk factors such as smoking, hypertension, and hyperlipidemia cannot entirely explain this elevation. It is thought that immunological dysfunction also increases CAD risk in SLE patients. The study aimed to assess early endothelial
changes in SLE Iraqi female patients without previous coronary artery lesions by
exploring a potential relationship between circulating VCAM-1 and ICAM-1 as
risk factors for atherosclerosis and the relationship of CAD with SLE disease and
its severity; further, the study explained the effect of the hydroxychloroquine
(HCQ) on the lipid profile levels of the patients. 92 female SLE patients were divided into mild, moderate, and severe, according to the SLE disease activity index
2000 (SLEDAI-2k), compared with 30 apparently healthy control individuals. All
of them need a history of CAD. Serum VCAM-1, ICAM-1 level, VCAM-1/ICAM1 ratio, TC, HDL, LDL levels TC/HDL and LDL/HDL ratios were measured.
sVCAM-1, sICAM-1 levels and VCAM-1/ICAM-1 ratio were significantly and
gradually increased in patient groups compared with control. Serum TC, HDL and
LDL levels were significantly reduced in the SLE patients compared to the control.
At the same time, the TC/HDL and LDL/HDL ratios were significantly elevated
with the severity of the SLE disease. sVCAM-1, sICAM-1 level and VCAM1/ICAM-1 ratio together with serum TC/HDL and LDL/HDL may improve coronary artery disease risk categorization in SLE patients without acute coronary syndromes. Furthermore, they were more sensitive in severe SLE instances than in
moderate and mild ones, suggesting that they may be related to the extent of coronary lesions in SLE patients. VCAM-1 had a higher sensitivity than ICAM-1 in
detecting and severity screening for CAD in SLE patients.
Keywords: VCAM-1, ICAM-1, SLE, Atherosclerosis
Subject
Infectious Diseases,Applied Microbiology and Biotechnology,Epidemiology,Biotechnology
Reference95 articles.
1. 1. Soliman MI, Esawy AM, Khashba SA. Role of prolactin in activity of systemic
2. lupus erythematosus. Egyptian Journal of Dermatology and Venerology. 2018 Jan
3. 1;38(1):23.
4. 2. Gregory Katz, Nathaniel R. Smilowitz, Ashira Blazer, Robert Clancy, Jill P. Buyon,
5. Jeffrey S. Berger, Systemic Lupus Erythematosus and Increased Prevalence of Atherosclerotic Cardiovascular Disease in Hospitalized Patients, Mayo Clinic Proceedings, Volume 94, Issue 8, 2019, Pages 1436-1443, ISSN 0025-6196.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献