Study of the relationship between genetic polymorphism of the IL-17 gene and vitamin D in asthmatic patients in Thi Qar Governorate

Abstract

This study was conducted at the Biotechnology Research Laboratory, Mazaya University College, from December to June 2022. This study included 150 samples (100 asthmatic patients and 50 healthy controls). The results showed that the highest incidence of asthma was in patients whose duration of illness ranged between (less than 14) years and reached (69%). The lowest incidence was in patients whose duration of illness ranged from (≥30) and more, reaching (6%), with a very high significant difference, which reached (0.00). The results of the current study showed the frequency of genotypes and alleles of the IL-17 gene for the two groups of patients and the comparison, as the percentage of genotype frequency (GG) in the comparison group was (46%) and in the group of patients (44%), without a significant difference, where the value of (OR = 1.00) The percentage of genotype frequency (AA) was in the comparison group (16%) and in the group of patients (32%), with a significant difference of (OR=2.09). As for the frequency of the genotype (GA), it was in the comparison group (38%) and the group of patients (24%) and without significant difference, where the value of (OR = 0.66). The current study showed vitamin D levels in both males and females (24.63 ± 15.54 / 23.01 ± 17.21), respectively, and without significant differences at the level of probability (0.05) (P.Value=0.794). Keyword: IL-17, asthmatic, Thi-Qar population