Vaccine Effectiveness Against Long COVID in Children-Reference-Cited by-同舟云学术

Vaccine Effectiveness Against Long COVID in Children

Published:2024-03-08 Issue:4 Volume:153 Page:
ISSN:0031-4005
Container-title:Pediatrics
language:en
Short-container-title:

Author:

Razzaghi Hanieh¹,Forrest Christopher B.¹²,Hirabayashi Kathryn¹,Wu Qiong³,Allen Andrea J.¹,Rao Suchitra⁴,Chen Yong³,Bunnell H. Timothy⁵,Chrischilles Elizabeth A.⁶,Cowell Lindsay G.⁷,Cummins Mollie R.⁸,Hanauer David A.⁹,Higginbotham Miranda¹,Horne Benjamin D.¹⁰,Horowitz Carol R.¹¹,Jhaveri Ravi¹²,Kim Susan¹³,Mishkin Aaron¹⁴,Muszynski Jennifer A.¹⁵,Naggie Susanna¹⁶,Pajor Nathan M.¹⁷,Paranjape Anuradha¹⁴,Schwenk Hayden T.¹⁸,Sills Marion R.¹⁹,Tedla Yacob G.²⁰,Williams David A.²¹,Bailey L. Charles¹²,

Affiliation:

1. aApplied Clinical Research Center, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

2. bDepartment of Pediatrics

3. cBiostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

4. dDepartment of Pediatrics, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora, Colorado

5. eBiomedical Research Informatics Center, Nemours Children’s Health, Wilmington, Delaware

6. fDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa

7. gPeter O’Donnell Jr School of Public Health; Department of Immunology, School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas

8. hCollege of Nursing, University of Utah, Salt Lake City, Utah

9. iDepartment of Learning Health Sciences, University of Michigan, Ann Arbor, Michigan

10. jIntermountain Heart Institute, Intermountain Health, Salt Lake City, Utah

11. kInstitute for Health Equity Research, Icahn School of Medicine at Mount Sinai, New York City, New York

12. lDivision of Infectious Diseases, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois

13. mDivision of Rheumatology, Benioff Children’s Hospital, University of California, San Francisco, San Francisco, California

14. nSection of Infectious Diseases, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania

15. oDivision of Critical Care Medicine, Department of Pediatrics, Nationwide Children’s Hospital, Columbus, Ohio

16. pDivision of Infectious Diseases, Duke University School of Medicine, Duke Clinical Research Institute, Durham, North Carolina

17. qDivision of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio

18. rDivision of Pediatric Infectious Diseases, Stanford School of Medicine, Palo Alto, California

19. sOCHIN, Inc, Portland, Oregon

20. tDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

21. uDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan

Abstract

OBJECTIVES Vaccination reduces the risk of acute coronavirus disease 2019 (COVID-19) in children, but it is less clear whether it protects against long COVID. We estimated vaccine effectiveness (VE) against long COVID in children aged 5 to 17 years. METHODS This retrospective cohort study used data from 17 health systems in the RECOVER PCORnet electronic health record program for visits after vaccine availability. We examined both probable (symptom-based) and diagnosed long COVID after vaccination. RESULTS The vaccination rate was 67% in the cohort of 1 037 936 children. The incidence of probable long COVID was 4.5% among patients with COVID-19, whereas diagnosed long COVID was 0.8%. Adjusted vaccine effectiveness within 12 months was 35.4% (95 CI 24.5–44.7) against probable long COVID and 41.7% (15.0–60.0) against diagnosed long COVID. VE was higher for adolescents (50.3% [36.6–61.0]) than children aged 5 to 11 (23.8% [4.9–39.0]). VE was higher at 6 months (61.4% [51.0–69.6]) but decreased to 10.6% (−26.8% to 37.0%) at 18-months. CONCLUSIONS This large retrospective study shows moderate protective effect of severe acute respiratory coronavirus 2 vaccination against long COVID. The effect is stronger in adolescents, who have higher risk of long COVID, and wanes over time. Understanding VE mechanism against long COVID requires more study, including electronic health record sources and prospective data.

Publisher

American Academy of Pediatrics (AAP)

Link

https://publications.aap.org/pediatrics/article-pdf/doi/10.1542/peds.2023-064446/1615235/peds.2023-064446.pdf

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