Post-COVID-19 condition at 6 months and COVID-19 vaccination in non-hospitalised children and young people

Author:

Pinto Pereira Snehal MORCID,Nugawela Manjula D,Rojas Natalia K,Shafran RozORCID,McOwat Kelsey,Simmons Ruth,Ford Tamsin,Heyman IsobelORCID,Ladhani Shamez NORCID,Cheung Emily Y,Fox-Smith Lana,Dalrymple Emma,Stephenson TerenceORCID

Abstract

ObjectivesTo describe the physical and mental health of children and young people (CYP) 6 months after infection with SARS-CoV-2 and explore whether this varies by COVID-19 vaccination.DesignA non-hospitalised, national cohort of people aged 11–17 years old with PCR-confirmed SARS-CoV-2 infection and PCR negatives matched at study invitation, by age, sex, region and date of testing who completed questionnaires 6 months after PCR testing. The questionnaire included 21 symptoms and standardised scales (eg, EQ-5D-Y and Chalder Fatigue Scale).Results6407 test-positive and 6542 test-negative CYP completed the 6-month questionnaire: 60.9% of test-positive vs 43.2% of test-negative CYP reported at least one symptom 6 months post-test; 27.6% of test-positive vs 15.9% of test-negative CYP reported 3+ symptoms. Common symptoms at 6 months were tiredness and shortness of breath among both test-positive and test-negative CYP; however, the prevalence of both was higher in test-positive (38.4% and 22.8%, respectively) compared with test-negative CYP (26.7% and 10.9%, respectively). 24.5% test-positive vs 17.8% test-negative CYP met the Delphi research definition of long COVID. Mental health, well-being, fatigue and health-related quality of life scores were similar among test-positive and test-negative CYP 6 months post-test. Similarly, symptomatology was similar among COVID-19-vaccinated and COVID-19-unvaccinated test-positive and test-negative CYP.ConclusionsSix-months post-PCR testing, CYP who tested positive for SARS-CoV-2 had similar symptoms to those who tested negative, but test-positive CYP had higher symptom prevalence. Mental health, well-being, fatigue and health-related quality of life were similar among test-positive and test-negative CYP, and symptoms at 6 months were similar in COVID-19 vaccinated and unvaccinated.Trial registration numberISRCTN 34804192.

Funder

National Institute for Health Research

Medical Research Council

The Department of Health and Social Care

Great Ormond Street Hospital

NIHR

NHS Foundation Trust

the NHS, the NIHR

Biomedical Research Centre

Publisher

BMJ

Reference25 articles.

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