Modern approaches to personalized neurology

Abstract

The article deals with an overview of modern concepts of personalized neurology — part of a continuum of personalized medicine. A brief historical and terminological essay is given, as well as a rationale for the importance of such an approach. Examples of promising areas of research on a wide range of biomarkers are described: biochemical, neurophysiological, angioneuroimaging, pathomorphological, etc. The issues of integrating the results of fundamental work in the field of neuroscience into clinical practice for the individualization of treatment are discussed. A general review of existing approaches to personalization in the diagnosis and therapy of the most significant neurological diseases is given: cerebrovascular pathology, epilepsy, demyelinating and neurodegenerative diseases. Future implications for the development of this area are identified and discussed, examples are described that reflect certain socio-economic aspects of personalization in neurology. The conclusion also lists a number of challenges facing this new direction in healthcare.