Personalized neurology

Abstract

The review presents the basic principles of personalized medicine in neurology, based on personified diagnostics, including approaches related to the analysis of the human genome, as well as the use of other omics technologies, such as neuroproteomics, neurometabolomics. The importance of taking into account the patient’s individual indicators (biomarkers) for the most accurate and timely diagnosis, monitoring the effectiveness and safety of therapy (theranostics) is discussed. Information on microRNAs with promising diagnostic potential is presented. The importance of pharmacogenomic studies for predicting the effectiveness of therapy is emphasized. The information on the study of the brain connectome and the mapping of the brain network is shown, which opens up new possibilities for understanding the physiological and pathological processes in the nervous system. The existing difficulties in the development of personalized medicine today are indicated and the undoubted benefits of individualized approaches in neurology are emphasized.