EVOLUTION OF THE VIEWS ON IMPORTANCE OF BLOOD PRESSURE VARIABILITY

Abstract

The phenomenon of variability of blood pressure (BP) has been studied for a long time, but recently, it has made a comeback in scientifi  c literature. This is mostly due to the fact that numerous studies have confirmed the importance of BP variability in predicting cardiovascular risk, although the effect of various parameters of variability does not have the same level of cardiovascular risk due to different underlying pathophysiological mechanisms. Interest in BP variability is due to and based on a series of studies carried out by P. Rothwell et al., who analyzed variability in BP in heterogeneous populations. In particular, the analysis of the ASCOT-BPLA trial showed high signifi  cance of intervisit variability of ВР and predicted stroke and coronary events. In light ofthese data, the variability of ВР is a promising new target for antihypertensive therapy. A statistically significant decrease of this index indicates the stability of the achieved results following treatment. The most convincing evidence in this respect, are those for the combination of amlodipine and perindopril.