Dietary (n-6 : n-3) Fatty Acids Alter Plasma and Tissue Fatty Acid Composition in Pregnant Sprague Dawley Rats

Author:

Kassem Amira Abdulbari12,Abu Bakar Md Zuki1,Yong Meng Goh1,Mustapha Noordin Mohamed3

Affiliation:

1. Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

2. Department of Animal Production, Faculty of Agriculture, University of Sana’a, P.O. Box 12426, Sana’a, Yemen

3. Department of Pathology and Microbiology Veterinary, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

Abstract

The objective of this paper is to study the effects of varying dietary levels ofn-6 : n-3fatty acid ratio on plasma and tissue fatty acid composition in rat. The treatment groups included control rats fed chow diet only, rats fed 50% soybean oil (SBO): 50% cod liver oil (CLO) (1 : 1), 84% SBO: 16% CLO (6 : 1), 96% SBO: 4% CLO (30 : 1). Blood samples were taken at day 15 of pregnancy, and the plasma and tissue were analyzed for fatty acid profile. Then-3PUFA in plasma of Diet 1 : 1 group was significantly higher than the other diet groups, while the totaln-6PUFA in plasma was significantly higher in Diet 30 : 1 group as compared to the control and Diet 1 : 1 groups. The Diet 1 : 1 group showed significantly greater percentages of totaln-3PUFA and docosahexaenoic acid in adipose and liver tissue, and this clearly reflected the contribution ofn-3fatty acids from CLO. The totaln-6PUFA, linoleic acid, and arachidonic acid were significantly difference in Diet 30 : 1 as compared to Diet 1 : 1 and control group. These results demonstrated that the dietary ratio ofn-6 : n-3fatty acid ratio significantly affected plasma and tissue fatty acids profile in pregnant rat.

Publisher

Hindawi Limited

Subject

General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine

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