Antioxidant Activity of Thiosulfonate Compounds in Experiments in Vitro and in Vivo

Abstract

The antioxidant activity of S-alkyl-4-aminobenzene-, S-allyl-4-aminobenzene- and 4-acetylaminobenzenethiosulfonates were determined by DPPH assay in experiments in vitro to establish the relationship between their structure and activity. Among the test compounds, the highest rates of these activities were found for S-allyl-4-aminobenzenethiosulfonate (ATS), S-ethyl-4-aminobenzene thiosulfonate (ETS), and S-allyl-acetyl-aminobenzenesulfonate (AATS). These compounds were studied in experiments in vivo. The processes of lipid peroxidation (LPO) and the state of the antioxidant system in the blood of rats under the influence of thiosulfonates were studied. The use of thiosulfonate additive to feed at a concentration of 100 mg/kg body weight of animals for 21 days did not cause pathological changes in rats' blood and positively influenced antioxidant blood levels.