Affiliation:
1. Tver State Medical University
2. Clinical Hospital No. 6
Abstract
Several vaccines from SARS-COV-2 are used in Russia, which have successfully passed all the stages of testing and showed their effectiveness.Purpose. The study was aimed to clarify the manifestations and course, severity of COVID-19 in SARS-CoV-2 vaccinated and unvaccinated patients.Materials and methods. 62 patients treated in an infectious hospital with a positive test for SARS-CoV-2 were examined. When selecting groups, the pseudorandomization method was used. Clinical symptoms of the disease, anamnesis data, results of pulse oximetry, computed tomography of the chest, clinical blood analysis, transaminase levels and hemostasis indicators were found out in all the examined patients.Results. The study showed that unvaccinated patients were hospitalized in a more serious condition, with significantly more pronounced volume of lung tissue damage and hypoxia. In the group of unvaccinated patients, there was a significantly higher incidence of liver damage and an increased risk of thrombosis. Unvaccinated patients had a significantly lower percentage of comorbid pathologies, and the vaccinated group was dominated by patientsConclusions. Vaccination from coronavirus infection does not exclude the development of the disease, but significantly reduces the frequency of its severe course.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
Reference17 articles.
1. Genomic characterization and epidemiology of 2019 novel coronavirus: Implications for virusoriginsand receptorbinding. Roujian Lu, Xiang Zhao, Juan Li, Peihua Niu, Bo Yang, Honglong Wu, Wenling Wang, Hao Song, Baoying Huang, Na Zhu, Yuhai Bi, Xuejun Ma, Faxian Zhan, Liang Wang, Tao Hu, Hong Zhou, Zhenhong Hu, Weimin Zhou, Li Zhao еt al. Lancet. 2020; 395 (10224): 565–574. doi.org/10.1016/S0140–6736(20)30251–8
2. Abdurakhimov A.H., Hegai L.N., Yusupova S.K. COVID 19 and its complications RE-Health J. 2021; 4 (12): 61–74.
3. Fomina L.A., Nemirov K.E., Sakharova E.M. Gastroenterological manifestations of SARS-COV 2 and possible consequences of infection. Experimental and clinical gastroenterology. 2022; 4 (200): 9–13. doi.org/10.31146/1682–8658-ecg200–4–9–13
4. Smirnov A. Yu. Analysis of mortality from coronavirus infection in Russia. Population. 2021; 24 (2): 76–86. DOI: 10.19181/population.2021.24.2.7.
5. Temporary methodological recommendations. Prevention, diagnosis and treatment of new coronavirus infection (COVID 19). Version 16. Avdeev S.N., Adamyan L. V., Alekseeva E. I., Bagnenko S. F. Baranov A. A., Baranova N. N., Belevsky A. S., Belkin A. A., Beloborodov V. B., Bodrova R. A., Buylova T. V., Boyko E. A., Briko N. I., Brusina E. B., Vavilova T. V., Vaisman D. Sh., Vasilyeva E. Yu., Vasilyeva I. A., Vasilyeva N. V. et al. Ministry OF Health OF the Russian Federation. 2022; 1–248.