1. From the Institute of Experimental and Clinical Pharmacology and Toxicology (A.E.-A., L.C., T.E.), Medical Center Hamburg-Eppendorf, Germany; Department of Pharmacology and Toxicology, University of Münster (P.B.), Münster, Germany; INSERM U582, University Pierre et Marie Curie, Paris, France (L.C.); and Cardiovascular Center (M.K.) and Department of Pharmacology and Toxicology (U.R., D.D.), Dresden University of Technology, Dresden, Germany.