1. From the Heart and Stroke/Richard Lewar Centre of Excellence, and Toronto General Research Institute, University Health Network, Toronto, Canada (Y.M., M.O., P.P.L.); the Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada (M.A.O.); and the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, Toronto and Ottawa, Canada (P.P.L.).