Affiliation:
1. Faculty of Pharmacy, Integral University, Dasauli Kursi Road, Lucknow, 226026, Uttar Pradesh, India
Abstract
Background:
The world is confronted with the threat of a pandemic driven by a novel coronavirus,
namely Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease was
spread in December 2019 in Wuhan (China). The virus has spread to 216 nations, regions, and territories
around the world. There were around 510306 confirmed cases and 333401 deaths by May 2020. Patients
with cardiovascular diseases and other co-morbidities were at a high risk of SARS-CoV-2 infection that
ultimately resulted in the death of the patient.
Objective:
This review highlights the impact of COVID-19 on cardiovascular diseases and other comorbidities.
Methods:
This review was completed using different sources of search sites like Google Scholar, Pub-
Med, ScienceDirect, Scopus, etc.
Result:
The diseases associated with the cardiovascular system include myocarditis, heart failure, cardiac
injury, and microangiopathy. The mechanisms that cause cardiovascular problems in COVID-19 are myocardial
injury pathways, systemic inflammation, altered myocardial demand and supply ratios, plaque
rupture, coronary thrombosis, adverse effects of various therapies, and electrolyte imbalances. Several
studies provide an important clinical and molecular clue to cardiac involvement during COVID-19. The
high cytokine concentrations may contribute to myocardial lesions and a poor disease prognosis. In an
earlier study, autopsy reports of COVID-19 found the SARS-CoV-2 genome in myocardial tissues. This
also demonstrates that cytokine-induced organ dysfunction contributes to the disease process.
Conclusion:
This review concludes that the impact of coronavirus on the cardiac system has shown a
harmful effect, and patients with co-morbidities are likely to be more affected by COVID-19 infection.
Publisher
Bentham Science Publishers Ltd.
Subject
Infectious Diseases,Virology,Pulmonary and Respiratory Medicine,Immunology and Microbiology (miscellaneous)