1. From the Department of Cardiology, Thoraxcenter (A.F.L.S., P.A.V., L.J.L.M.J., F.J.T.C., M.M.) and Department of Internal Medicine, Section of Pharmacology, Vascular and Metabolic Diseases (A.F.L.S., E.J.G.S.), Erasmus MC, Rotterdam, The Netherlands.