Historical Lessons in Translational Medicine

Author:

Fitzgerald Desmond J.1,FitzGerald Garret A.1

Affiliation:

1. UCD Conway Institute and Java Clinical Research, University College Dublin, Ireland (D.J.F.); and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA (G.A.F.).

Abstract

The development of drugs that inhibit platelets has been driven by a combination of clinical insights, fundamental science, and sheer luck. The process has evolved as the days of stumbling on therapeutic gems, such as aspirin, have long passed and have been replaced by an arduous process in which a drug is designed to target a specific protein implicated in a well-characterized pathophysiological process, or so we would like to believe. The development of antiplatelet therapy illustrates the importance of understanding the mechanisms of disease and the pharmacology of the compounds we develop, coupled with careful clinical experimentation and observation and, yes, still, a fair bit of luck.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference174 articles.

1. Experiences with aspirin (acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis.;Craven LL;Miss Valley Med J,1953

2. BLEEDING-TIME AFTER ASPIRIN INGESTION

3. The effect of salicylates on the hemostatic properties of platelets in man

4. EFFECTS OF SALICYLATES ON HUMAN PLATELETS

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