Inflammation in Myocardial Diseases

Author:

Marchant David J.1,Boyd John H.1,Lin David C.1,Granville David J.1,Garmaroudi Farshid S.1,McManus Bruce M.1

Affiliation:

1. From the James Hogg Research Centre and Institute for Heart + Lung Health (D.J.M., J.H.B., D.C.L., D.J.G., F.S.G., B.M.M.), Department of Pathology and Laboratory Medicine (D.J.M., D.C.L., D.J.G., F.S.G., B.M.M.), Department of Medicine (J.H.B.), University of British Columbia, Providence Health Care, Vancouver, Canada.

Abstract

Inflammatory processes underlie a broad spectrum of conditions that injure the heart muscle and cause both structural and functional deficits. In this article, we address current knowledge regarding 4 common forms of myocardial inflammation: myocardial ischemia and reperfusion, sepsis, viral myocarditis, and immune rejection. Each of these pathological states has its own unique features in pathogenesis and disease evolution, but all reflect inflammatory mechanisms that are partially shared. From the point of injury to the mobilization of innate and adaptive immune responses and inflammatory amplification, the cellular and soluble mediators and mechanisms examined in this review will be discussed with a view that both beneficial and adverse consequences arise in these human conditions.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

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