EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SIDDHA HERBOMINERAL FORMULATION RATHINAGARA RASA MEZHUGU IN ANIMAL MODEL
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Published:2023-12-01
Issue:
Volume:
Page:48-50
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ISSN:
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Container-title:INDIAN JOURNAL OF APPLIED RESEARCH
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language:en
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Short-container-title:IJAR
Author:
Parvathy R. S1, Mariappan A.2, Kumari R. Meena3
Affiliation:
1. PG Scholar, Department of Gunapadam, National Institute of Siddha, Ministry of AYUSH, Chennai-600047 2. Associate Professor, Department of Gunapadam, National Institute of Siddha, Ministry of AYUSH, Chennai-600047. 3. Director/Professor, Department of Gunapadam, National Institute of Siddha, Ministry of AYUSH, Chennai-600047
Abstract
The usage of Nonsteroidal and steroidal drugs in the treatment of Musculoskeletal disorders often results in adverse
effects such as renal damage, gastric irritation, etc. Alternative therapies with less or no side effects are the need of the
hour. Siddha system offers a lot of Anti-inammatory drugs that are polyherbal or Herbo-mineral in nature and devoid of the above-mentioned
adverse effects. This research work deals with the Anti-inammatory screening of a Siddha Herbo-mineral Formulation Rathinagara rasa
mezhugu (RNM) documented in classic Siddha literature Anuboga vaidhaya naveneetham Part 5 indicated for inammatory disease conditions.
Anti-inammatory activity was evaluated by Carrageenan-induced paw edema in Wistar rats. Indomethacin (10 mg/kg, orally) was used as
standard. The formulation in doses of 20mg/kg, 45mg/kg, and 90 mg/kg showed 56%, 61.53%, and 90.47% inhibition of paw edema, respectively
at the end of 5 h. The result of the study showed that RNM at all dose levels signicantly(p<0.5) reduced the inammation in a dose-dependent
manner when compared to the control. RNM at 90mg/kg was found to be signicant (**p<0.01) and effective in the reduction of paw edema after
5hrs.From the results, it can be concluded that Rathinagara rasa mezhugu (RNM) was found to exhibit high anti-inammatory potential which
conrmed the traditional use of the drug.
Publisher
World Wide Journals
Subject
Cellular and Molecular Neuroscience,Developmental Neuroscience,Neurology,Toxicology,General Neuroscience,Toxicology,General Neuroscience,Cellular and Molecular Neuroscience,Developmental Neuroscience,Toxicology,Nuclear and High Energy Physics,Atomic and Molecular Physics, and Optics,Anthropology,Visual Arts and Performing Arts,Speech and Hearing,Public Health, Environmental and Occupational Health,Otorhinolaryngology,Mechanical Engineering,Acoustics and Ultrasonics,Mechanics of Materials,Condensed Matter Physics,General Materials Science,General Engineering,Industrial and Manufacturing Engineering,Public Health, Environmental and Occupational Health,Mechanical Engineering,Acoustics and Ultrasonics,Aerospace Engineering,Automotive Engineering,Building and Construction
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