Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes-Reference-Cited by-同舟云学术

Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes

Published:2024-01-19 Issue:2 Volume:134 Page:189-202
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

Julla Jean-Baptiste¹²³⁴^ORCID,Girard Diane¹²³,Diedisheim Marc¹²³⁵,Saulnier Pierre-Jean⁶^ORCID,Tran Vuong Bao¹²³^ORCID,Blériot Camille¹²³^ORCID,Carcarino Elena¹²³^ORCID,De Keizer Joe⁷^ORCID,Orliaguet Lucie¹²³,Nemazanyy Ivan¹^ORCID,Potier Charline¹²³,Khider Kennan¹²³^ORCID,Tonui Dorothy Chepngenoh¹²³,Ejlalmanesh Tina¹²³,Ballaire Raphaelle¹²³,Mambu Mambueni Hendrick⁸^ORCID,Germain Stéphane⁹^ORCID,Gaborit Bénédicte¹⁰¹¹^ORCID,Vidal-Trécan Tiphaine³⁴^ORCID,Riveline Jean-Pierre¹²³⁴^ORCID,Garchon Henri-Jean⁸^ORCID,Fenaille François¹²^ORCID,Lemoine Sophie¹³^ORCID,Carlier Aurélie¹⁴,Castelli Florence¹²^ORCID,Potier Louis¹²³¹⁴,Masson David¹⁵¹⁶¹⁷¹⁸^ORCID,Roussel Ronan¹²³¹⁴,Vandiedonck Claire¹²³^ORCID,Hadjadj Samy⁷^ORCID,Alzaid Fawaz¹²³¹⁹^ORCID,Gautier Jean-François¹²³⁴^ORCID,Venteclef Nicolas¹²³^ORCID

Affiliation:

1. INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Université Paris Cité, France.

2. Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Université (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Université Paris Cité, France.

3. Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Université Paris Cité, France.

4. Diabetology, Endocrinology and Nutrition Department, Lariboisière Hospital, Fédération de Diabétologie, France (J.-B.J., T.V.-T., J.-P.R., J.-F.G.).

5. Clinique Saint Gatien Alliance (NCT+), Saint-Cyr-sur-Loire, France (M.D.).

6. Poitiers Université, CHU Poitiers, INSERM, Centre d’Investigation Clinique CIC1402, Poitiers, France (P.-J.S.).

7. Nantes Université, CHU Nantes, CNRS, INSERM, l’institut du thorax, Nantes, France (J.D.K., S.H.).

8. Genomics platform UFR Simone Veil 1173; U, University of Versailles Paris-Saclay; Inserm UMR 1173 (H.M.M., H.-J.G.).

9. Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Université PSL, Paris, France (S.G.).

10. C2VN, INRAE, INSERM, Aix Marseille University, Marseille, France (B.G.).

11. Department of Endocrinology, Metabolic Diseases and Nutrition, Pôle ENDO, AP-HM, Marseille, France (B.G.).

12. Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), MetaboHUB, France (F.F., F.C.).

13. Genomics core facility, Institut de Biologie de l’ENS (IBENS), Département de biologie, École Normale Supérieure, CNRS, INSERM, Université PSL, Paris, France (S.L.).

14. Diabetology and Endocrinology Department, Bichat Hospital, Fédération de Diabétologie, France (L.P., A.C., R.R.).

15. INSERM, LNC UMR1231, Dijon, France (D.M.).

16. University of Bourgogne and Franche-Comté, LNC UMR1231, Dijon, France (D.M.).

17. FCS Bourgogne-Franche Comté, LipSTIC LabEx, Dijon, France (D.M.).

18. Plateau Automatisé de Biochimie, Dijon University Hospital, France (D.M.).

19. Dasman Diabetes Institute, Kuwait (F.A.).

Abstract

BACKGROUND: Diabetes is a major risk factor for atherosclerotic cardiovascular diseases with a 2-fold higher risk of cardiovascular events in people with diabetes compared with those without. Circulating monocytes are inflammatory effector cells involved in both type 2 diabetes (T2D) and atherogenesis. METHODS: We investigated the relationship between circulating monocytes and cardiovascular risk progression in people with T2D, using phenotypic, transcriptomic, and metabolomic analyses. cardiovascular risk progression was estimated with coronary artery calcium score in a cohort of 672 people with T2D. RESULTS: Coronary artery calcium score was positively correlated with blood monocyte count and frequency of the classical monocyte subtype. Unsupervised k-means clustering based on monocyte subtype profiles revealed 3 main endotypes of people with T2D at varying risk of cardiovascular events. These observations were confirmed in a validation cohort of 279 T2D participants. The predictive association between monocyte count and major adverse cardiovascular events was validated through an independent prospective cohort of 757 patients with T2D. Integration of monocyte transcriptome analyses and plasma metabolomes showed a disruption of mitochondrial pathways (tricarboxylic acid cycle, oxidative phosphorylation pathway) that underlined a proatherogenic phenotype. CONCLUSIONS: In this study, we provide evidence that frequency and monocyte phenotypic profile are closely linked to cardiovascular risk in patients with T2D. The assessment of monocyte frequency and count is a valuable predictive marker for risk of cardiovascular events in patients with T2D. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04353869

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

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