Nomenclature of monocytes and dendritic cells in blood

Author:

Ziegler-Heitbrock Loems12,Ancuta Petronela3,Crowe Suzanne4,Dalod Marc567,Grau Veronika8,Hart Derek N.9,Leenen Pieter J. M.10,Liu Yong-Jun11,MacPherson Gordon12,Randolph Gwendalyn J.13,Scherberich Juergen14,Schmitz Juergen15,Shortman Ken16,Sozzani Silvano17,Strobl Herbert18,Zembala Marek19,Austyn Jonathan M.20,Lutz Manfred B.21

Affiliation:

1. Helmholtz Zentrum München, Gauting, Germany;

2. Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom;

3. Université de Montréal, Centre Hospitalier de l'Universite de Montreal (CHUM), and Inserm Unit 743, Montreal, QC;

4. Macfarlane Burnet Institute for Medical Research, Melbourne, Australia;

5. Centre d'Immunologie de Marseille-Luminy (CIML), Université de la Méditerranée, Marseille, France;

6. Inserm U631, Marseille, France;

7. Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 6102, Marseille, France;

8. Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, University of Giessen, Giessen, Germany;

9. Anzac Research Institute, Sydney, Australia;

10. Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands;

11. Department of Immunology, University of Texas, M. D. Anderson Cancer Center, Houston, TX;

12. Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom;

13. Mount Sinai School of Medicine, New York, NY;

14. Klinik für Nephrologie und Klinische Immunologie, Municipal Hospital Harlaching, Ludwig-Maximilians-University, Muenchen, Germany;

15. Department of Research and Development, Miltenyi Biotec, Bergisch Gladbach, Germany;

16. The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;

17. Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy;

18. Institute of Immunology, Medical University Vienna, Wien, Austria;

19. Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Krakow, Poland;

20. Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and

21. Institute for Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany

Abstract

AbstractMonocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense. Over recent years these cells have been characterized in detail with the use of cell surface markers and flow cytometry, and subpopulations have been described. The present document proposes a nomenclature for these cells and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and 3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendritic cells) in human and in mouse blood. This classification has been approved by the Nomenclature Committee of the International Union of Immunological Societies, and we are convinced that it will facilitate communication among experts and in the wider scientific community.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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