Affiliation:
1. Department of Medicine, Georgetown University School of Medicine, and the Georgetown Medical Division of the District of Columbia General Hospital, Washington, D. C.
Abstract
These data demonstrate that in normal subjects angiotensin II is 10 times as potent as norepinephrine, which it resembles hemodynamically. An increase in the systolic pressure is associated with significant increase in diastolic pressure, increase in venous pressure, decrease in heart rate, slight decrease in cardiac output with striking increase in total peripheral resistance, decrease in renal blood flow, decreased glomerular filtration rate, increase in filtration fraction, arid slight decrease in urinary volume.
Preliminary studies of patients in shock suggest that angiotensin II is two or three times as potent as norepinephrine. Continuous administration is not associated with the development of resistance or tachyphylaxis, nor does sloughing of tissues occur when there is leakage outside the vein.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Cited by
41 articles.
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