Examination of the Relationship of Renin Release to Hypertension Produced in the Rabbit by Renal-Artery Constriction

Abstract

Plasma samples taken from the renal veins of rabbits hypertensive following renal-artery constriction were examined for evidence of increased renin content. No increase in the activity of the renal-vein samples was found as compared with plasma obtained from other sites in these rabbits, or with samples taken from unoperated animals. By contrast, renin infused into the renal veins of rabbits to give comparable elevation of the arterial pressure was, in all cases, detected. The experimental findings are discussed in relation to current views of the role of renin in experimental hypertension in the rabbit.