Sir William Stanley Peart. 31 March 1922—14 March 2019

Author:

Gordon David1

Affiliation:

1. World Federation for Medical Education, 13A Chemin du Levant, 01210 Ferney-Voltaire, France

Abstract

Sir Stanley Peart began his academic career with two fine original pieces of work: elucidating the neurotransmitter discharged from sympathetic nerves to the viscera; and characterizing the amino-acid sequence of angiotensin, the peptide released by the action of the enzyme renin. The influence of both these lines of work has been profound. First, on the understanding of neurotransmission in the autonomic nervous system, the peripheral nervous system that regulates involuntary processes in the viscera. Second, on the control of the vascular system; on hypertension and the design of antihypertensive drugs; on creation of analogues and antagonists of angiotensin; and on the therapeutic potential of inhibitors of angiotensin-converting enzyme. These achievements required intense application, originality of ideas and technique and good scientific taste in the choice of collaborators. However, he chose not to remain in the laboratory, but explicitly to be a clinician scientist, with his research growing from and illuminated by clinical practice. He created a fruitful and durable school of research in hypertension and the related subjects, inspiring and influencing a generation of clinician scientists. Among his strengths were the ability to analyse and constructively criticize research, and to recognize the aptitudes and abilities of all who had the pleasure of working with him. His academic career began as a medical student at St Mary's Hospital Medical School in London, and he spent almost all of his career at St Mary's, including 31 years as professor of medicine.

Publisher

The Royal Society

Reference36 articles.

1. Blythe M. 1993 Sir Stanley Peart FRS in interview with Dr Max Blythe: interviews 1–5. RADAR: institutional repository of Oxford Brookes University. Oxford Brookes University. See https://doi.org/10.24384/000236; https://doi.org/10.24384/000057; https://doi.org/10.24384/000055; https://doi.org/10.24384/000234; https://doi.org/10.24384/000056; https://doi.org/10.24384/000235 (accessed 4 December 2023).

2. Suggested Revision of Nomenclature—Angiotensin

3. Plasma renin concentration in human hypertension

4. Tansey E. M. Christie D. A. & Reynolds L. A. 1998 In Wellcome witnesses to twentieth century medicine: volume 2. Queen Mary University of London pp. 114–116. See http://qmro.qmul.ac.uk/xmlui/handle/123456789/2746 (accessed 4 December 2023).

5. Wikipedia. 2023 Jack Peart. See https://en.wikipedia.org/wiki/Jack_Peart (accessed 4 December 2023).

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