1. From the Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI (S.W.W., A.M.D., B.S., J.M.T., R.B., G.D.F.); ChemoCentryx, Inc, Mountain View, CA (M.E.P., T.J.S., T.T.C.); and Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada (J.L.R., C.J.S.).