Chemerin is resident to vascular tunicas and contributes to vascular tone-Reference-Cited by-同舟云学术

Chemerin is resident to vascular tunicas and contributes to vascular tone

Published:2023-07-01 Issue:1 Volume:325 Page:H172-H186
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Wabel Emma¹^ORCID,Orr Alexis¹,Flood Emma D.¹,Thompson Janice M.¹,Xie Huirong²,Demireva Elena Y.²,Abolibdeh Bana²,Honke Hulbert Darcy³,Mullick Adam E.⁴^ORCID,Garver Hannah¹,Fink Gregory D.¹^ORCID,Kung Theodore A.⁵,Watts Stephanie W.¹^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States

2. Transgenic and Genome Editing Facility, Research Technology Support Facility, and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan, United States

3. Cardiovascular Division, Campus Animal Resources, Michigan State University, East Lansing, Michigan, United States

4. Ionis Pharmaceuticals, Carlsbad, California, United States

5. Section of Plastic and Reconstructive Surgery, Department of Surgery, Michigan Medicine, Ann Arbor, Michigan, United States

Abstract

Vascular tunicas synthesizing chemerin is a new finding. Vascular chemerin is independent of hepatic-derived chemerin. Vasculature from both males and females have resident chemerin. Chemerin1 receptor activity supports vascular tone.

Funder

American Heart Association

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00239.2023

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