Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease

Author:

Fahed Akl C.1ORCID,Aragam Krishna G.2,Hindy George3ORCID,Chen Yii-Der Ida4,Chaudhary Kumardeep5ORCID,Dobbyn Amanda5,Krumholz Harlan M.6ORCID,Sheu Wayne H.H.7ORCID,Rich Stephen S.8ORCID,Rotter Jerome I.4ORCID,Chowdhury Rajiv9,Cho Judy5,Do Ron5,Ellinor Patrick T.2ORCID,Kathiresan Sekar10ORCID,Khera Amit V.1ORCID

Affiliation:

1. Center for Genomic Medicine & Division of Cardiology, Department of Medicine, Massachusetts General Hospital & Department of Medicine, Harvard Medical School, Boston & Cardiovascular Disease Initiative, Program in Medical and Population Genetics, Broad Institute of MIT & Harvard, Cambridge, MA

2. Division of Cardiology, Department of Medicine, Massachusetts General Hospital & Department of Medicine, Harvard Medical School, Boston & Cardiovascular Disease Initiative, Program in Medical and Population Genetics, Broad Institute of MIT & Harvard, Cambridge, MA

3. Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar

4. The Institute for Translational Genomics & Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA

5. Charles Bronfman Institute for Personalized Medicine, Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY

6. Section of Cardiovascular Medicine & the Robert Wood Johnson Clinical Scholars Program, Department of Medicine, Yale University School of Medicine, New Haven, CT

7. Taichung Veterans General Hospital, Department of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan

8. Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA

9. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

10. Division of Cardiology, Department of Medicine, Massachusetts General Hospital & Department of Medicine, Harvard Medical School, Boston & Program in Medical and Population Genetics, Broad Institute of MIT & Harvard & Verve Therapeutics, Cambridge, MA

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

Reference18 articles.

1. Khera AV Chaffin M Aragam KG Haas ME Roselli C Choi SH Natarajan P Lander ES

2. Lubitz SA Ellinor PT etal. Genome-wide polygenic scores for common diseases identify

3. with risk equivalent to monogenic mutations;Nat Genet.,2018

4. Aragam KG Dobbyn A Judy R Chaffin M Chaudhary K Hindy G Cagan A Finneran P

5. Weng L-C Loos RJF etal. Limitations of Contemporary Guidelines for Managing Patients at

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