Rare Protein-Truncating Variants in APOB , Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease

Author:

Peloso Gina M.1,Nomura Akihiro2,Khera Amit V.34,Chaffin Mark3,Won Hong-Hee5,Ardissino Diego67,Danesh John8910,Schunkert Heribert11,Wilson James G.12,Samani Nilesh1314,Erdmann Jeanette15,McPherson Ruth16,Watkins Hugh17,Saleheen Danish18,McCarthy Shane19,Teslovich Tanya M.19,Leader Joseph B.20,Lester Kirchner H.20,Marrugat Jaume21,Nohara Atsushi2,Kawashiri Masa-aki2,Tada Hayato2,Dewey Frederick E.19,Carey David J.20,Baras Aris19,Kathiresan Sekar34

Affiliation:

1. Department of Biostatistics, Boston University School of Public Health, MA (G.M.P.).

2. Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan (A. Nomura, A. Nohara, M.K., H.T.).

3. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (A.V.K., M.C., S.K.).

4. Cardiovascular Research Center (A.V.K., S.K.), Center for Genomic Medicine (A.V.K., S.K.), and Department of Medicine (A.V.K., S.K.), Massachusetts General Hospital, Boston, MA.

5. Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea (H.-H.W.).

6. Cardiology, Azienda Ospedaliero-Universitaria di Parma, University of Parma, Parma, Italy (D.A.).

7. ASTC: Associazione per lo Studio Della Trombosi in Cardiologia, Pavia, Italy (D.A.).

8. MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (J.D.), University of Cambridge, Cambridge, United Kingdom.

9. The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health & Genomics (J.D.), University of Cambridge, Cambridge, United Kingdom.

10. Wellcome Trust Sanger Institute, Genome Campus, Hinxton, United Kingdom (J.D.).

11. Deutsches Herzzentrum München, Technische Universität München, Deutsches Zentrum für Herz-Kreislauf-Forschung, München, Germany (H.S.).

12. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS (J.G.W.).

13. Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (N.S.).

14. NIHR Leicester Biomedical Research Center, Glenfield Hospital, Leicester, United Kingdom (N.S.).

15. Institute for Integrative and Experimental Genomics, University of Lübeck, Germany (J.E.).

16. University of Ottawa Heart Institute, Ottawa, Canada (R.M.).

17. Cardiovascular Medicine, Radcliffe Department of Medicine and Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, United Kingdom (H.W.).

18. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (D.S.).

19. Regeneron Genetics Center, Tarrytown, NY (S.M., T.M.T., F.E.D., A.B.).

20. Geisinger Health System, Danville, PA (J.B.L., H.L.K., D.J.C.).

21. Registre Gironí del Cor group, IMIM (Hospital del Mar Research Institute), Barcelona, Spain (J.M.). CIBER Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain (J.M.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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