ApoB100 and Atherosclerosis: What’s New in the 21st Century?-Reference-Cited by-同舟云学术

ApoB100 and Atherosclerosis: What’s New in the 21st Century?

Published:2024-02-12 Issue:2 Volume:14 Page:123
ISSN:2218-1989
Container-title:Metabolites
language:en
Short-container-title:Metabolites

Author:

Kounatidis Dimitris¹^ORCID,Vallianou Natalia G.²^ORCID,Poulaki Aikaterini³^ORCID,Evangelopoulos Angelos⁴,Panagopoulos Fotis²,Stratigou Theodora⁵^ORCID,Geladari Eleni²,Karampela Irene⁶^ORCID,Dalamaga Maria⁷^ORCID

Affiliation:

1. Second Department of Internal Medicine, Hippokration General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece

2. Department of Internal Medicine, Evangelismos General Hospital, 10676 Athens, Greece

3. Hematology Unit, Second Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece

4. Roche Diagnostics Hellas S.A., 15125 Athens, Greece

5. Department of Endocrinology and Metabolism, Evangelismos General Hospital, 10676 Athens, Greece

6. Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece

7. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

Abstract

ApoB is the main protein of triglyceride-rich lipoproteins and is further divided into ApoB48 in the intestine and ApoB100 in the liver. Very low-density lipoprotein (VLDL) is produced by the liver, contains ApoB100, and is metabolized into its remnants, intermediate-density lipoprotein (IDL) and low-density lipoprotein (LDL). ApoB100 has been suggested to play a crucial role in the formation of the atherogenic plaque. Apart from being a biomarker of atherosclerosis, ApoB100 seems to be implicated in the inflammatory process of atherosclerosis per se. In this review, we will focus on the structure, the metabolism, and the function of ApoB100, as well as its role as a predictor biomarker of cardiovascular risk. Moreover, we will elaborate upon the molecular mechanisms regarding the pathophysiology of atherosclerosis, and we will discuss the disorders associated with the APOB gene mutations, and the potential role of various drugs as therapeutic targets.

Publisher

MDPI AG

Link

https://www.mdpi.com/2218-1989/14/2/123/pdf

Reference175 articles.

1. Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat;Zheng;J. Lipid. Res.,2006

2. Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish;Shen;Arch. Intern. Med.,2010

3. The changing landscape of atherosclerosis;Libby;Nature,2021

4. Nguyen, M.T., Fernando, S., Schwarz, N., Tan, J.T., Bursill, C.A., and Psaltis, P.J. (2019). Inflammation as a Therapeutic Target in Atherosclerosis. J. Clin. Med., 8.

5. Behbodikhah, J., Ahmed, S., Elyasi, A., Kasselman, L.J., De Leon, J., Glass, A.D., and Reiss, A.B. (2021). Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target. Metabolites, 11.

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