Affiliation:
1. University of California San Francisco (J.J.M.).
2. Texas Children’s Hospital (A.M.Q., V.A.).
3. Cincinnati Children’s Hospital Medical Center (B.H.G., C.S.C.).
4. Children’s Healthcare of Atlanta (C.J.P., C.E.M., M.S.K., H.B.-H., R.A.L.).
5. Children’s Hospital of Philadelphia (A.J.G., A.C.G.).
6. Vanderbilt University Medical Center (G.T.N.).
Abstract
Background:
Patients with single ventricle anatomy and ductal-dependent pulmonary blood flow may be initially palliated with either modified Blalock-Taussig shunt (BTS) or ductus arteriosus stent (DAS). Comparisons of outcomes during the interstage period and at the time of superior cavopulmonary connection (SCPC) are lacking and may differ between palliation strategies.
Methods:
Infants with single ventricle anatomy and ductal-dependent pulmonary blood flow palliated with either DAS or BTS from 2008 to 2015 were reviewed across 4 centers. Interstage outcomes, and for those who had SCPC, anatomy, hemodynamics, and perioperative clinical outcomes were compared. Thirty-five patients with DAS and 136 patients with BTS were included.
Results:
At initial palliation, demographic, clinical variables, and pulmonary artery size were similar. Interstage death, transplant, or unplanned reintervention to treat cyanosis occurred in 25.7% of DAS and 35.8% of BTS,
P
=0.27. Reintervention was more common with DAS (48.6% versus 2.2%;
P
<0.001). Twenty-three DAS patients and 111 BTS patients underwent SCPC. Preoperative hemodynamics and overall pulmonary artery growth were similar, although right pulmonary artery growth was better with DAS (change in
z
-score: 1.57 versus 0.65,
P
=0.026). SCPC intraoperative and postoperative courses were similar.
Conclusions:
In patients with single-ventricle anatomy and ductal-dependent pulmonary blood flow, interstage outcomes, hemodynamics before SCPC, and acute postoperative outcomes were similar. Overall reintervention was more common in the DAS group, driven by more frequent planned reintervention. Unplanned reintervention, death, and transplant were similar. Both groups demonstrated good pulmonary artery growth. DAS is a reasonable initial palliative alternative to BTS in select patients.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine