1. From the Department of Experimental Medicine and Toxicology (B.K., L.M., M.R.W.), Imperial College London, London, United Kingdom; National Center of Cardiology and Internal Medicine (A.A., M.K., A.P., A.J.), Bishkek, Kyrgyz Republic; and the Genomic and Molecular Medicine (M.T.), Clinical Sciences Centre, Medical Research Council, London, United Kingdom.