Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment

Author:

Sliz Eeva123,Kettunen Johannes123,Holmes Michael V.4567,Williams Clare Oliver89,Boachie Charles10,Wang Qin12311,Männikkö Minna12,Sebert Sylvain1313,Walters Robin5,Lin Kuang5,Millwood Iona Y.5,Clarke Robert5,Li Liming1415,Rankin Naomi16,Welsh Paul16,Delles Christian16,Jukema J. Wouter17,Trompet Stella1718,Ford Ian10,Perola Markus192021,Salomaa Veikko19,Järvelin Marjo-Riitta132223,Chen Zhengming5,Lawlor Debbie A.724,Ala-Korpela Mika123724,Danesh John82526,Davey Smith George724,Sattar Naveed16,Butterworth Adam825,Würtz Peter1627

Affiliation:

1. Center for Life Course Health Research (E.S., J.K., Q.W., S.S., M.-R.J., M.A.-K.), University of Oulu, Finland.

2. Computational Medicine, Faculty of Medicine (E.S., J.K., Q.W., M.A.-K.), University of Oulu, Finland.

3. Biocenter Oulu, Oulu, Finland (E.S., J.K., Q.W., S.S., M.-R.J., M.A.-K.).

4. Medical Research Council Population Health Research Unit (M.V.H.), University of Oxford, United Kingdom.

5. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (M.V.H., R.W., K.L., I.Y.M., R.C., Z.C.), University of Oxford, United Kingdom.

6. National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, United Kingdom (M.V.H.).

7. Medical Research Council Integrative Epidemiology Unit (M.V.H., D.A.L., M.A.-K., G.D.S.), University of Bristol, United Kingdom.

8. MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (C.O.W., J.D., A.B.), University of Cambridge, United Kingdom.

9. Homerton College (C.O.W.), University of Cambridge, United Kingdom.

10. Robertson Centre for Biostatistics (C.B., I.F.), University of Glasgow, United Kingdom.

11. Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (Q.W., M.A.-K.).

12. Northern Finland Birth Cohorts, Faculty of Medicine (M.M.), University of Oulu, Finland.

13. Department of Genomics of Complex Diseases, School of Public Health, Imperial College London, United Kingdom (S.S.).

14. Chinese Academy of Medical Sciences, Beijing, China (L.L.).

15. Department of Global Health, School of Public Health, Peking University, Beijing, China (L.L.).

16. Institute of Cardiovascular and Medical Sciences (N.R., P.W., C.D., N.S.), University of Glasgow, United Kingdom.

17. Department of Cardiology (J.W.J., S.T.), Leiden University Medical Center, The Netherlands.

18. Department of Internal Medicine, Section of Gerontology and Geriatrics (S.T.), Leiden University Medical Center, The Netherlands.

19. National Institute for Health and Welfare, Helsinki, Finland (M.P., V.S.).

20. Institute for Molecular Medicine Finland, University of Helsinki (M.P.).

21. University of Tartu, Estonian Genome Center, Estonia (M.P.).

22. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, United Kingdom (M.R.-J.).

23. Unit of Primary Care, Oulu University Hospital, Oulu, Finland (M.R.-J.).

24. Population Health Science, Bristol Medical School (D.A.L., M.A-.K., G.D.S.), University of Bristol, United Kingdom.

25. National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics (J.D., A.B.), University of Cambridge, United Kingdom.

26. Wellcome Trust Sanger Institute, Hinxton, United Kingdom (J.D.).

27. Diabetes and Obesity Research Program, University of Helsinki, Finland (P.W.). Nightingale Health Ltd, Helsinki, Finland (P.W.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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