Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth

Author:

Li Mingchuan1,Sala Valentina12,De Santis Maria Chiara1,Cimino James1,Cappello Paola3,Pianca Nicola45,Di Bona Anna456,Margaria Jean Piero1,Martini Miriam1,Lazzarini Edoardo7,Pirozzi Flora18,Rossi Luca1,Franco Irene1,Bornbaum Julia9,Heger Jacqueline9,Rohrbach Susanne9,Perino Alessia1,Tocchetti Carlo G.8,Lima Braulio H.F.10,Teixeira Mauro M.10,Porporato Paolo E.1,Schulz Rainer9,Angelini Annalisa6,Sandri Marco45,Ameri Pietro7,Sciarretta Sebastiano11,Lima-Júnior Roberto César P.112,Mongillo Marco45,Zaglia Tania456,Morello Fulvio2,Novelli Francesco3,Hirsch Emilio1,Ghigo Alessandra1

Affiliation:

1. Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Italy (M.L., V.S., M.C.D.S., J.C., J.P.M., M.M., F.P., L.R., I.F., A.P., P.E.P., R.C.P.L.-J., E.H., A.G.)

2. A.O.U. Città della Salute e della Scienza di Torino, S.C. Emergency Medicine, Torino, Italy (V.S., F.M.).

3. Center for Experimental Research and Medical Studies, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Italy (P.C., F.N.)

4. Department of Biomedical Sciences, University of Padova, Italy (N.P., A.D.B., M.S., M.M., T.Z.)

5. Venetian Institute of Molecular Medicine, Padova, Italy (N.P., A.D.B., M.S., M.M., T.Z.)

6. Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Italy (A.D.B., A.A., T.Z.)

7. Department of Internal Medicine, Cardiovascular Biology Laboratory, University of Genova and IRCCS Policlinic Hospital San Martino, Italy (E.L., P.A.)

8. Department of Translational Medical Sciences, Division of Internal Medicine, Federico II University, Napoli, Italy (F.P., C.G.T.)

9. Institut für Physiologie, Justus Liebig University Giessen, Germany (J.B., J.H., S.R., R.S.)

10. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (B.H.F.L., M.M.T.)

11. Department of Medical and Surgical Sciences and Biotechnologies, University of Rome Sapienza, Latina, Italy (S.S.)

12. Department of Physiology and Pharmacology, Laboratory of Pharmacology of Inflammation and Cancer, Universidade Federal do Ceará/UFC, Fortaleza, Brazil (R.C.P.L.-J.)

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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