Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis
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Published:2017-09-12
Issue:11
Volume:136
Page:1007-1021
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ISSN:0009-7322
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Container-title:Circulation
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language:en
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Short-container-title:Circulation
Author:
Adriaenssens Tom1, Joner Michael1, Godschalk Thea C.1, Malik Nikesh1, Alfonso Fernando1, Xhepa Erion1, De Cock Dries1, Komukai Kenichi1, Tada Tomohisa1, Cuesta Javier1, Sirbu Vasile1, Feldman Laurent J.1, Neumann Franz-Josef1, Goodall Alison H.1, Heestermans Ton1, Buysschaert Ian1, Hlinomaz Ota1, Belmans Ann1, Desmet Walter1, ten Berg Jurrien M.1, Gershlick Anthony H.1, Massberg Steffen1, Kastrati Adnan1, Guagliumi Giulio1, Byrne Robert A.1
Affiliation:
1. From Department of Cardiology, University Hospitals Leuven and Department of Cardiovascular Sciences, KU Leuven, Belgium (T.A., D.D.C., W.D.); Deutsches Herzzentrum München, Technische Universität München, Germany (M.J., E.X., T.T., A.K., R.A.B.); Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands (T.C.G., J.M.t.B.); Department of Cardiovascular Sciences, University of Leicester & Leicester NIHR Cardiovascular Biomedical Research Unit, Glenfield Hospital, United Kingdom...
Abstract
Background:
Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST.
Methods:
Consecutive patients presenting with ST were prospectively enrolled in a registry by using a centralized telephone registration system. After angiographic confirmation of ST, OCT imaging of the culprit vessel was performed with frequency domain OCT. Clinical data were collected according to a standardized protocol. OCT acquisitions were analyzed at a core laboratory. Dominant and contributing findings were adjudicated by an imaging adjudication committee.
Results:
Two hundred thirty-one patients presenting with ST underwent OCT imaging; 14 (6.1%) had image quality precluding further analysis. Of the remaining patients, 62 (28.6%) and 155 (71.4%) presented with early and late/very late ST, respectively. The underlying stent type was a new-generation drug-eluting stent in 50.3%. Mean reference vessel diameter was 2.9±0.6 mm and mean reference vessel area was 6.8±2.6 mm
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. Stent underexpansion (stent expansion index <0.8) was observed in 44.4% of patients. The predicted average probability (95% confidence interval) that any frame had uncovered (or thrombus-covered) struts was 99.3% (96.1–99.9), 96.6% (92.4–98.5), 34.3% (15.0–60.7), and 9.6% (6.2–14.5) and malapposed struts was 21.8% (8.4–45.6), 8.5% (4.6–15.3), 6.7% (2.5–16.3), and 2.0% (1.2–3.3) for acute, subacute, late, and very late ST, respectively. The most common dominant finding adjudicated for acute ST was uncovered struts (66.7% of cases); for subacute ST, the most common dominant finding was uncovered struts (61.7%) and underexpansion (25.5%); for late ST, the most common dominant finding was uncovered struts (33.3%) and severe restenosis (19.1%); and for very late ST, the most common dominant finding was neoatherosclerosis (31.3%) and uncovered struts (20.2%). In patients presenting very late ST, uncovered stent struts were a common dominant finding in drug-eluting stents, and neoatherosclerosis was a common dominant finding in bare metal stents.
Conclusions:
In patients with ST, uncovered and malapposed struts were frequently observed with the incidence of both decreasing with longer time intervals between stent implantation and presentation. The most frequent dominant observation varied according to time intervals from index stenting: uncovered struts and underexpansion in acute/subacute ST and neoatherosclerosis and uncovered struts in late/very late ST.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference32 articles.
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