1. From the Department of Cardiology (L.C., G.M.D.F., A.V., P.J.S.), University of Pavia, and IRCCS Policlinico S. Matteo, Pavia; Molecular Cardiology Laboratory (L.C., R.I., M.P., C.F., P.J.S.), IRCCS Policlinico S. Matteo, Pavia, Italy; and the Departments of Pharmacology (A.L.L., P.Y., D.M.R., A.L.G.) and Medicine (D.M.R., A.L.G.), Vanderbilt University, Nashville, Tennessee.