1. From the Division of Endocrinology and Metabolism, Department of Internal Medicine (X.Y., K.Murao, H.I., W.-M.C., J.L., K.Matsumoto, T.N., R.A.M.A., T.I.), and Department of Cardiovascular Physiology (H.K.), Faculty of Medicine, Kagawa University, Kagawa, Japan; the Departments of Medicine and Biochemistry and Molecular Biology (N.C.W.W.), Faculty of Medicine, University of Calgary, Health Sciences Center, Calgary, Alberta, Canada; and the Departments of Medicine and Physiology and Biophysics (T.G.U...