1. From the School of Physiology and Pharmacology, Bristol Heart Institute, Medical Sciences Building, University of Bristol, Bristol, United Kingdom (H.W., E.B.H., M.T., S.K., J.F.R.P.); Department of Physiology, Wakayama Medical University, Wakayama, Japan (H.W., S.G.); and Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom (C.C.T.H., D.M.).