1. From the Departments of Medicine and Pharmacology, Division of Clinical Pharmacology (D.K., E.A.F., M.M., G.G.S., A.J.J.W., C.M.S.), and the Department of Biomedical Statistics (W.D.D.), Vanderbilt University School of Medicine, Nashville, Tenn; the Department of Pharmacology, Drug Development and Therapeutics (M.S.), University of Turku, and Clinical Pharmacology, TYKSLAB, Hospital District of Southwest Finland, Turku, Finland.