The Efficacy and Safety of Dexmedetomidine for Procedural Sedation in Patients Receiving Local Anesthesia Outside the Intensive Care Unit: A Prospective, Double-Blind, Randomized Clinical Phase III Trial in Japan-Reference-Cited by-同舟云学术

The Efficacy and Safety of Dexmedetomidine for Procedural Sedation in Patients Receiving Local Anesthesia Outside the Intensive Care Unit: A Prospective, Double-Blind, Randomized Clinical Phase III Trial in Japan

Published:2022 Issue:1 Volume:65 Page:26-43
ISSN:1346-8049
Container-title:Yonago Acta Medica
language:en
Short-container-title:Yonago Acta Med.

Author:

Inagaki Yoshimi¹,Morita Kiyoshi²,Ozaki Makoto³,Matsumoto Kazuo⁴,Okayama Akifumi⁵,Oya Nobuyo⁶,Hiraoka Takehiko⁶,Takeda Junzo⁷

Affiliation:

1. Department of Anesthesiology and Critical Care Medicine, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan

2. Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan

3. Department of Anesthesiology, Tokyo Women’s Medical University, Tokyo 162-8666, Japan

4. Department of Cardiology, Saitama Medical University International Medical Center, Hidaka 350-1298; and Higashimatsuyama Medical Association Hospital, Higashimatsuyama 355-0021, Japan

5. Clinical Statistics Group 2, Biometrics & Data Management, Pfizer R&D Japan, Tokyo 151-8589, Japan

6. Clinical Development Department, Maruishi Pharmaceutical Co., Ltd., Osaka 538-0042, Japan

7. Department of Anesthesiology, Keio University School of Medicine, Tokyo 151−8589, Japan; and National Hospital Organization, Tokyo Medical Center, Tokyo 152-8902, Japan

Publisher

Tottori University Faculty of Medicine

Subject

General Medicine

Link

https://www.jstage.jst.go.jp/article/yam/65/1/65_2022.02.005/_pdf

Reference21 articles.

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2. 2. Hall JE, Uhrich TD, Barney JA, Arain SR, Ebert TJ. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg. 2000;90:699-705. PMID:10702460, DOI:10.1097/00000539-200003000-00035

3. 3. Forster A, Gardaz JP, Suter PM, Gemperle M. Respiratory depression by midazolam and diazepam. Anesthesiology. 1980;53:494-7. PMID:7457966, DOI:10.1097/00000542-198012000-00010

4. 4. Blouin RT, Seifert HA, Babenco HD, Conard PF, Gross JB. Propofol depresses the hypoxic ventilatory response during conscious sedation and isohypercapnia. Anesthesiology. 1993;79:1177-82. PMID:8267192, DOI:10.1097/00000542-199312000-00007

5. 5. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000;93:382-94. PMID:10910487, DOI:10.1097/00000542-200008000-00016

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