Endothelial Function in Hypertension

Author:

McIntyre Martin1,Bohr David F.1,Dominiczak Anna F.1

Affiliation:

1. From the Department of Medicine and Therapeutics (M.M., A.F.D.), Gardiner Institute, Western Infirmary, Glasgow, UK; and the Department of Physiology (D.F.B.), University of Michigan, Ann Arbor.

Abstract

Abstract —Much attention has been focused on the role of nitric oxide in hypertension and cardiovascular disease. More recently, the role of superoxide anion and its interaction with nitric oxide has been investigated in this context. This review will concentrate on the role of superoxide in human and experimental hypertension, paying particular attention to the potential sources of superoxide within the vasculature and discussing some of the molecular mechanisms surrounding its production and dismutation. We discuss what is known about the human superoxide dismutase enzymes. We conclude that the balance between nitric oxide and superoxide is more important than the absolute levels of either alone.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

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